Metabolic Disorders


METABOLISM IMMUNE DISEASE Uniqueness and Strength of Yacobi Biomedical Therapeutics. Metabolic and immune systems are among the most fundamental requirements for survival. Immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly: obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare. Why are metabolic diseases so common and why are they so crucially linked to inflammatory processes?

VISION ON IMMUNE RESPONSE, metabolic disorders and possible treatments in modern day life, we are confronted with increased amounts of antigens, including those caused by the ever denser traffic and changed consumption habits. If antigens make it into the blood stream, they combine with circulating antibodies (immunoglobulin IgA – IgM) to produce Circulating Immune Complexes (CICs). Bacteria, viruses, toxins, and some drugs also give rise to formation of CICs. CICs are usually removed from the circulation in a healthy individual by a number of complex biochemical, enzymatic, and cellular processes. Under certain disease conditions, immune complexes may not be efficiently eliminated from the body. CICs not removed for any reason, may end up accumulating in certain soft organs tissues, where they may trigger a cascade of events which lead to multiple symptoms, progressing in the worst case to inflammatory disease in target organs.
Certain white blood cells (lymphocytes) called T-cells, may be activated by immune complexes. T-cells will trigger immune reactions with the release of cytokines such as interleukin, interferon and Tumor necrosis factor (TNF, or TNFα).

Metabolic disorders are caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. Inherited metabolic disorders are caused by a defect in a single gene. There are many inborn errors of metabolism. Some produce relatively unimportant physical features or skeletal abnormalities. Others produce serious disease and even death.

Some of the more familiar inborn errors of metabolism are cystic fibrosis, hypothyroidism, sickle cell anemia, phenylketonuria (PKU) and Tay-Sachs disease. Inborn errors of metabolism affect about 1 in every 5,000 babies born. Parents who have had one child with an inborn error of metabolism are at risk to have other affected children.

One in 4 pregnancies of such couples is expected to result in an affected child. Some inborn errors of metabolism are more often found in certain racial and ethnic groups. Sickle cell anemia, for example, is found among those of African and Semitic descent. Those of European heritage are more likely to pass on defective genes for cystic fibrosis. The children of women with some inborn errors of metabolism are at risk because of an unfavorable environment in the womb.

There has been an explosion in knowledge concerning the immune system, and tremendous advancements in disease diagnosis and therapies with novel approaches – predominantly biologic- based treatments – replacing the traditional methods where emphasis was to treat the symptoms in order to improve the quality of life of the patient rather than treating the underlying cause of the disease. Over the past 25 years Scientist Dr. Yacobi had been doing a colossal effort by helping many ill patients when it comes to metabolism immune diseases. This new approach to immune disease has resulted in a wealth of new a formula called Maysarah® or MayX® that selectively target the causes of immune disease.